components study on antitussive effect and holistic mechanism

Components study on antitussive effect and holistic mechanism

The antitussive effect of Platycodonis Radix is closely related to the components in saponins fraction of Platycodonis Radix extract (SFPRE); however, these active components and their holistic mechanism remain unknown. Hence, a new method by integrating spectrum-effect relationship analysis with me …

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pharmacokinetic pilot study of the antiangiogenic activity

Pharmacokinetic Pilot Study of the Antiangiogenic Activity

Results. Platycodin radix extract, platycodin D, and platycodi radix extract standardized to platycodin D all inhibited angiogenesis. The three volunteers who consumed platycodi radix extract standardized to 414 mg of platycodin D had a 25.76% reduction in angiogenesis from baseline at 60 minutes (P<0.002), and had a statistically significant reduction in angiogenesis from 30 to 240 minutes (P

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bioactive platycodins from platycodonis radix: phytochemistry

Bioactive platycodins from Platycodonis Radix: Phytochemistry

Aside from the platycodins enriched extracts of Platycodonis Radix, purified platycodins including platycodin A, C, D and deapioplatycodin D showed inhibitory effect against the enzymatic activity of pancreatic lipase at the concentration of 500 μg/mL, which served as a potential mechanism of their anti-obesity activity (Xu, Han, Zheng, Lee

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platycodon grandiflorum root extract

platycodon grandiflorum root extract

PubMed: Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. PubMed: Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity.

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publications about radix platycodonis

Publications about Radix platycodonis

November/16/2015. Abstract. Platycodin D (PD), isolated from the Chinese medicinal herb named Platycodonis Radix, is a triterpenoid saponin with well-known anti-tumor effects. In this study, we provided reliable evidence that PD triggered autophagy in a number of cell lines in vitro.

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establishment of indirect competitive enzyme linked

Establishment of indirect competitive enzyme linked

immunosorbent assay for the detection of platycodin D in Radix Platycodonis. Shuai Luo. 1, Yanfei He. 1, Hongxiang Sun* College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Abstract Platycodin D (PD) has been used as the quality control marker of Radix Platycodonis for its high content and various pharmacological

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determination of platycodin d and platycodin d3 in rat plasma

Determination of Platycodin D and Platycodin D3 in Rat Plasma

The oral bioavailability of platycodin D and platycodin D3 was 0.29% and 1.35% in rats at 500 mg/kg of 3% PD extract of PG, respectively. The present method can be applied to pharmacokinetic analysis of platycodins and platycosides of the PG.

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pharmacokinetic pilot study of the antiangiogenic activity

Pharmacokinetic pilot study of the antiangiogenic activity

Platycodin radix extract, platycodin D, and platycodi radix extract standardized to platycodin D all inhibited angiogenesis. The three volunteers who consumed platycodi radix extract standardized to 414 mg of platycodin D had a 25.76% reduction in angiogenesis from baseline at 60 minutes ( P <0.002), and had a statistically significant

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platycodon grandiflorum root extract

platycodon grandiflorum root extract

PubMed: Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. PubMed: Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity.

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an hplc-ms/ms method for the quantitative determination

An HPLC-MS/MS method for the quantitative determination

To develop an HPLC-MS/MS method for the quantification of platycodin D (PD) in rat plasma, and to acquire the main pharmacokinetic parameters of PD after oral administration of pure PD or of Platycodi Radix extract (PRE) containing PD. Method Plasma samples were pretreated with solid-phase extraction using an Oasis® HLB SPE cartridge.

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(pdf) in vitro inhibitory effect of triterpenoidal saponins

(PDF) In vitro inhibitory effect of triterpenoidal saponins

Aside from the platycodins enriched extracts of Platycodonis Radix, purified platycodins including platycodin A, C, D and deapioplatycodin D showed inhibitory effect against the enzymatic activity

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influence of sulfur fumigation on glycoside profile in

Influence of sulfur fumigation on glycoside profile in

Ma et al. Chin Med DOI 10.1186/s13020-016-0101-1 RESEARCH Influence of sulfur fumigation on glycoside profile in Platycodonis Radix (Jiegeng)Xiao‑Qing Ma1†, Su‑Mei Li1†, Chi Leung Chan1, Tao Su1, Wei‑Dong Li1, Hui Cao2, Wang‑Fun Fong 1

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platycodin d | ≥99%(hplc) | selleck | immunology

Platycodin D | ≥99%(HPLC) | Selleck | Immunology

Platycodin D. For research use only. Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties. Next day delivery by 10:00 a.m. Order now.

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biotransformation of food-derived saponins, platycosides

Biotransformation of Food-Derived Saponins, Platycosides

In addition, the enzyme completely converted platycoside E (PE), platycodin D 3 (PD 3), and platycodin D (PD) in Platycodi radix extract into deglucosylated platycodin D (deglu PD), which was first identified by nuclear magnetic resonance.

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simultaneous determination of various platycosides in four

Simultaneous determination of various platycosides in Four

Qin Z, Zhang F, Shou-Hong G, Fei C, Jiang B, Lian-Na S, Wan-Sheng C (2014) An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract. Chin J Nat Med 12:154–160. Google Scholar 18.

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platycodin radix extracts, and their use in treating disease

Platycodin Radix Extracts, and Their Use in Treating Disease

Extracts of radix platycodin are used to inhibit angiogenesis, particularly angiogenesis that is associated with disease conditions other than obesity or cancer. Platycodin Radix Extracts, and Their Use in Treating Disease Conditions Associated with Angiogenesis - GREENWAY FRANK L.

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antiproliferative effects of saponins from the roots

Antiproliferative Effects of Saponins from the Roots

Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D2 (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1−3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or

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china iso certificated manufacturer supply 100% natural radix

China ISO Certificated Manufacturer Supply 100% Natural Radix

Radix Platycodonis P. E Extract, Platycodi Radix, Balloon Flower Root manufacturer / supplier in China, offering ISO Certificated Manufacturer Supply 100% Natural Radix Platycodonis P. E Extract, Platycodon Grandiflorum, Radix Aucklandiae Extract, Aucklandia Root Herbal Extract, Plant Extract, Folium Isatidis P. E. Extract, Plant Extract, Herbal Extract and so on.

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molecules | free full-text | quantitative and chemical

Molecules | Free Full-Text | Quantitative and Chemical

Platycodin D 3 contents were within a range of 0.282–5.650 mg/g. Deapioplatycodin D and platycodin D 2 contents were lower than 1.623 mg/g and 1.355 mg/g, respectively. The contents of platycodin D ranged from 0.234 to 6.822 mg/g, whereas polygalacin D contents were within a range of 0.195–2.171 mg/g.

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platycodin d induces apoptosis and triggers erk- and jnk

Platycodin D induces apoptosis and triggers ERK- and JNK

Platycodin D (PD) is one of the main saponins extracted from Platycodonis radix, and it possesses immune-stimulatory 2, anti-inflammatory 3,4, anti-nociceptive 5, anti-obesity 5,6, and anti

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long-term consumption of saponins derived from platycodi

Long-term consumption of saponins derived from Platycodi

This was explained by the platycodin D contained in Chinese Platycodi radix, which inhibits pancreatic lipase in vitro to reduce fat absorption (Reference Han, Zheng, Xu, Okuda and Kimura 21). Since the suppression of fat absorption is part of the lipid metabolism, the involvement of fat oxidation and/or fat synthesis in the reduction of

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killing cancer with platycodin d through multiple mechanisms

Killing cancer with platycodin D through multiple mechanisms

The root of P. grandiflorum called Platycodonis Radix 56 or Platycodi Radix 44, 57 is a well‐known Traditional Chinese Medicine used as an expectorant for pulmonary diseases and a remedy for respiratory disorders including cough, colds, sore throat, tonsillitis and chest congestion 54, 58.

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radix bupleuri: a review of traditional uses, botany

Radix Bupleuri: A Review of Traditional Uses, Botany

However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b 2 , c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri .

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the healing power of platycodon grandiflorus extract for your

The Healing Power of platycodon grandiflorus extract for Your

Buy amazing platycodon grandiflorus extract on Alibaba.com at irresistible offers and enhance your well-being. The proven health benefits of platycodon grandiflorus extract will leave you with a smile.

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the healing power of platycodon root powder for your health

The Healing Power of platycodon root powder for Your Health

Organic Natural 98% Platycodin D Platycodon Grandiflorus Root Natural Saponin 25% Radix Platycodonis P.E/Radix Platycodonis Extract Powder. US $20.00-$50.00

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hypocholesterolemic and anti‐obesity effects of saponins from

Hypocholesterolemic and Anti‐Obesity Effects of Saponins from

ABSTRACT: Platycodins, a group of saponin glycosides from Platycodon grandiflorum, are believed to possess anti‐obesity and cholesterol‐lowering properties.The aim of the present study was to investigate whether dietary platycodins affect plasma, hepatic, or fecal cholesterol concentrations, as well as cholesterol absorption and fractional synthesis rates in a dose‐dependent manner.

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